Efficient inhibition of muscle and liver glycogen phosphorylases by a new glucopyranosylidene-spiro-thiohydantoin

E Osz; L Somsák; L Szilágyi; L Kovács; T Docsa; B Tóth; P Gergely

doi:10.1016/s0960-894x(99)00192-4

Efficient inhibition of muscle and liver glycogen phosphorylases by a new glucopyranosylidene-spiro-thiohydantoin

Bioorg Med Chem Lett. 1999 May 17;9(10):1385-90. doi: 10.1016/s0960-894x(99)00192-4.

Authors

E Osz¹, L Somsák, L Szilágyi, L Kovács, T Docsa, B Tóth, P Gergely

Affiliation

¹ Department of Organic Chemistry, Lajos Kossuth University, Debrecen, Hungary.

PMID: 10360741
DOI: 10.1016/s0960-894x(99)00192-4

Abstract

Reaction of C-(1-bromo-1-deoxy-beta-glucopyranosyl)formamide 2 with thiocyanate ions was the key step of a short synthesis of D-glucopyanosylidene-spiro-thiohydantoin 7 which proved to be a potent inhibitor of muscle and liver glycogen phosphorylases.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Enzyme Inhibitors / pharmacology*
Kinetics
Liver / drug effects*
Liver / enzymology
Muscle, Skeletal / drug effects*
Muscle, Skeletal / enzymology
Phosphorylases / antagonists & inhibitors*
Rabbits

Substances

Enzyme Inhibitors
Phosphorylases